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KLINIČKO-PATOLOŠKA OBILJEŽJA MIKROPAPILARNE VARIJANTE UROTELNOG KARCINOMA MOKRAĆNOG MJEHURA
CLINICOPATHOLOGICAL CHARACTERISTICS OF MICROPAPILLARY VARIANT OF URINARY BLADDER CARCINOMA PETRA RADULOVIĆ, IVANA PAVIĆ, ZLATKO MARUŠIĆ, MELITA PERIĆ-BALJA, ARIANA ZNAOR, OGNJEN KRAUS, BOŽO KRUŠLIN Deskriptori: Urotelni karcinom – dijagnoza, patologija; Mikropapilarni karcinom – dijagnoza, patologija; Mokraćni mjehur, tumori – dijagnoza, patologija
Sažetak. Mikropapilarni urotelni karcinom (MUK) je rijetka varijanta urotelnog karcinoma mjehura (UK) koja ima veoma agresivno ponašanje. U ovoj studiji analizirali smo kliničkopatološka obilježja MUK, posebno odnos između patohistološkog stupnja u trenutku otkrivanja bolesti i udjela mikropapilarne komponente (MPK) u pregledanom materijalu za 10 bolesnika koji su liječeni zbog urotelnog karcinoma mjehura u razdoblju od 1. 1. 2004.–30. 6. 2007. u KB Sestre milosrdnice. U promatranom razdoblju bilo je 610 bolesnika s UK mjehura (M:F=456:154), od kojih je 10 imalo MUK. Svi mikropapilarni urotelni karcinomi bili su u invazivnom stadiju bolesti u vrijeme postavljanja dijagnoze. Raspodjela po stadijima bila je 4 T1 (40%) i 6 T2 ( 60%) a udio MPK bio je: u 3 od 4 (75%) T1 tumora manje od 10% MPK, dok je u 5 od 6 (83,3%) T2 tumora bilo više od 50% MPK. MUK je agresivni tumor, obično u uznapredovalom stadiju u vrijeme otkrivanja bolesti, kod kojeg je patološki stadij povezan s udjelom MPK u tumoru.
Descriptors: Carcinoma, transitional cell – diagnosis, pathology; Carcinoma, papillary – diagnosis, pathology; Urinary bladder neoplasms – diagnosis, pathology
Summary. Micropapillary urothelial carcinoma (MUC) is a rare variant of urinary bladder carcinoma associated with highly aggressive behaviour. The aim of this study was to analyse clinicopathological features of MUC particularly a relationship between pathological stage at presentation and proportion of micropapillary component (MPC) in 10 patients with MUC. In the examined period (January 1st, 2004 – June 30th, 2007) there were 610 patients with urinary bladder cancer (M:F=456:154), while 10 (1.6%) of them were patients with MUC. All MUC were invasive at the time of diagnosis. Stage distribution at presentation was 4 T1 (40%) and 6 T2 (60%) and the percentage of MPC correlated with pathological stage: 3 of 4 (75%) tumors staged T1 had less than 10% of MPC and 5 of 6 (83,3%) tumors staged T2 had more than 50% of MPC. MUC is an aggressive tumor, often in advanced stage of disease at the time of diagnosis, in which the pathological stage is ¬related to the proportion of MPC. Liječ Vjesn 2008;130:1–3 |
