Summary. The thyreoglossal cyst may be located in the intralingual, suprahyoid, thyrohyoid or suprasternal region. Its position in the hyoid bone is extremely rare. In this paper a 62-year-old patient with a big thyreoglossal duct cyst situated in the corps of the hyoid bone is described. Besides a painless solid swelling in the medial neck region, the patient had swallowing and breathing problems, which is unspecific for thyreoglossal duct cyst. By removing the hyoid bone with thyreoglossal duct cyst, the patient’s problems completely disappeared and during 1 year long observation no sickness relapse has been noted.