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<article article-type="research-article" dtd-version="1.0" xml:lang="hr" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">LV</journal-id>
<journal-id journal-id-type="nlm-ta">Lijec Vjesn</journal-id>
<journal-title-group>
<journal-title>Lijecnicki Vjesnik</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Lijec. Vjesn.</abbrev-journal-title>
</journal-title-group>
<issn pub-type="ppub">0024-3477</issn>
<issn pub-type="epub">1849-2177</issn>
<publisher><publisher-name>Croatian Medical Association</publisher-name></publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">LV-144-357</article-id>
<article-id pub-id-type="doi">10.26800/LV-144-11-12-1</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original article</subject></subj-group>
</article-categories>
<title-group>
<article-title>Depression, anxiety and stress among medical students during COVID-19 pandemic</article-title>
<trans-title-group xml:lang="en">
<trans-title>Depresivnost, anksioznost i stres me&#x0111;u studentima medicine tijekom pandemije COVID-19</trans-title>
</trans-title-group>
</title-group>
<contrib-group>
<contrib contrib-type="author"><name><surname>&#x0160;imle&#x0161;a</surname><given-names>Dinko</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7830-224X</contrib-id><name><surname>Aukst Margeti&#x0107;</surname><given-names>Branka</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib>
<aff id="aff1"><label>1</label>Klini&#x010D;ka bolnica &#x201E;Sveti Duh&#x201C;, <addr-line>Zagreb</addr-line></aff>
<aff id="aff2"><label>2</label><institution>Klinika za psihijatriju, Klini&#x010D;ki bolni&#x010D;ki centar Sestre milosrdnice</institution>, <addr-line>Zagreb</addr-line></aff>
<aff id="aff3"><label>3</label>Medicinski fakultet Sveu&#x010D;ili&#x0161;ta u Zagrebu</aff>
</contrib-group>
<author-notes>
<fn id="afn1"><p>Rad je napravljen kao diplomski rad na Medicinskom fakultetu Sveu&#x010D;ili&#x0161;ta u Zagrebu.</p></fn>
<corresp id="cor1">Adresa za dopisivanje: Doc. dr. sc. Branka Aukst Margeti&#x0107;, <ext-link ext-link-type="uri" xlink:href="https://orcid.org/0000-0002-7830-224X">https://orcid.org/0000-0002-7830-224X</ext-link> &#x2028;Klinika za psihijatriju KBC Sestre milosrdnice, Vinogradska 29, 10000 Zagreb, e-po&#x0161;ta: <email xlink:href="brankaaukstmargetic@gmail.com">brankaaukstmargetic@gmail.com</email></corresp></author-notes>
<pub-date pub-type="epub-ppub"><month>12</month><year>2022</year></pub-date>
<volume>144</volume>
<issue>11-12</issue>
<fpage>357</fpage>
<lpage>364</lpage>
<permissions>
<copyright-year>2022</copyright-year>
<copyright-holder>Croatian Medical Association</copyright-holder>
<license xlink:href="https://creativecommons.org/licenses/by-nc-nd/4.0/" specific-use="CC BY-NC-ND 4.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND) 4.0 License.</license-p></license>
</permissions>
<abstract>
<title>SA&#x017D;ETAK</title>
<sec><title>Cilj</title><p>U vrijeme pandemije COVID-19 promjene u uvjetima studiranja mogu utjecati na mentalno zdravlje studenata medicine. Istra&#x017E;ivanje ima za cilj ispitati pojavnost depresije, anksioznosti i stresa, njihovu povezanost sa sociodemografskim i akademskim karakteristikama te postojanje razlika izme&#x0111;u studenata pretklini&#x010D;kih i klini&#x010D;kih godina studija.</p></sec>
<sec><title>Metode</title><p>Ovo presje&#x010D;no istra&#x017E;ivanje provedeno je <italic>online</italic> uporabom metode snje&#x017E;ne grude. Uklju&#x010D;eno je 206 studenata svih godina Medicinskog fakulteta Sveu&#x010D;ili&#x0161;ta u Zagrebu, od &#x010D;ega je 51% pripadalo skupini pretklini&#x010D;kih, a 49% skupini klini&#x010D;kih godina studija.</p></sec>
<sec><title>Rezultati</title><p>Istra&#x017E;ivanje je ukazalo na prisutnost depresije u 25,7% studenata medicine, 26,7% je imalo zna&#x010D;ajne anksiozne smetnje, a 15% zna&#x010D;ajne simptome stresa. Simptomi anksioznosti i stresa bili su vi&#x0161;e izra&#x017E;eni u studentica. Korelacijska analiza ukazala je na obrnutu povezanost depresije, anksioznosti i stresa s prosje&#x010D;nim uspjehom, depresije s godinom studija, a vrijeme provedeno u u&#x010D;enju obrnuto je koreliralo s anksiozno&#x0161;&#x0107;u. U logisti&#x010D;koj regresiji su prosjek ocjena i partnerski status (biti u vezi) bili zna&#x010D;ajni prediktori depresije, prosjek ocjena, spol i konzumacija psihoaktivnih tvari zna&#x010D;ajni prediktori anksioznosti, dok su spol i konzumacija psihoaktivnih tvari bili zna&#x010D;ajni prediktori stresa. Preboljenje COVID-19 kao i cijepljenje protiv ove bolesti nije bilo povezano s depresijom, anksiozno&#x0161;&#x0107;u i stresom. Cijepljenje je bilo &#x010D;e&#x0161;&#x0107;e &#x0161;to su studenti stariji, odnosno &#x010D;e&#x0161;&#x0107;e u skupini klini&#x010D;kih godina studija.</p></sec>
<sec><title>Zaklju&#x010D;ak</title><p>U doba pandemije lo&#x0161;ije mentalno zdravlje studenata medicine povezano je sa &#x017E;enskim spolom, lo&#x0161;ijim akademskim uspjehom, partnerskim statusom i konzumacijom psihoaktivnih tvari. Preboljenje COVID-19 kao i cijepljenje protiv COVID-19 nije bilo povezano s mentalnim zdravljem.</p></sec>
</abstract>
<trans-abstract xml:lang="en">
<title>SUMMARY</title>
<sec><title>Aim</title><p>At the time of COVID-19 pandemic the terms of studying medicine have considerably changed, which could lead to worse mental health of medical students. The study aims to assess the presence of depression, anxiety and stress, categorised to preclinical and clinical groups of students, and their association with sociodemographic and academic characteristics.</p></sec>
<sec><title>Methods</title><p>This cross-sectional study was conducted on-line using snowball method. Two hundred and six students at the Medical School, University of Zagreb were included, of whom 51% were in the group of preclinical and 49% in the group of clinical years.</p></sec>
<sec><title>Results</title><p>The study showed the presence of depression in 25.7% of medical students, 26.7% had significant symptoms of anxiety, and 15% of stress. Anxiety and stress were significantly higher in female students. Correlation analysis showed a negative association between depression, anxiety, stress and average grades, between depression and the year of the study, and the time spent in learning correlated negatively with anxiety. In logistic regression average grades and partner status (being in a relationship) were the main predictors of depression. Average grades, gender, and consumption of psychoactive substances were significant predictors of anxiety. Gender and psychoactive substances consumption were significant predictors of stress. Overcoming COVID-19 and vaccination against it were not associated with depression, anxiety and stress. Vaccination was associated with older age and was significantly more common in the clinical years group.</p></sec>
<sec><title>Conclusion</title><p>In time of the pandemic worse mental health of medical students was associated with female gender,lower academic grades, partner status, and consumption of psychoactive substances. Overcoming COVID-19 and vaccination against it were not associated with mental health.</p></sec>
</trans-abstract>
<kwd-group kwd-group-type="author"><kwd>Deskriptori STUDENTI MEDICINE &#x2013; psihologija</kwd><kwd>DEPRESIJA &#x2013; epidemiologija, psihologija</kwd><kwd>ANKSIOZNOST &#x2013; epidemiologija, psihologija</kwd><kwd>PSIHOLO&#x0160;KI STRES &#x2013; epidemiologija, psihologija</kwd><kwd>MENTALNO ZDRAVLJE</kwd><kwd>COVID-19 &#x2013; psihologija</kwd><kwd>PANDEMIJA</kwd><kwd>ANKETE I UPITNICI</kwd></kwd-group>
<kwd-group kwd-group-type="translator" xml:lang="en"><title>Descriptors </title><kwd>STUDENTS, MEDICAL &#x2013; psychology</kwd><kwd>DEPRESSION &#x2013; epidemiology, psychology</kwd><kwd>ANXIETY &#x2013; epidemiology, psychology</kwd><kwd>STRESS, PSYCHOLOGICAL &#x2013; epidemiology, psychology</kwd><kwd>MENTAL HEALTH</kwd><kwd>COVID-19 &#x2013; psihologija</kwd><kwd>PANDEMICS</kwd><kwd>SURVEYS AND QUESTIONNAIRES</kwd></kwd-group>
</article-meta>
</front>
<body>
<p>Pandemija koronavirusa dovela je do porasta pojavnosti psihi&#x010D;kih poreme&#x0107;aja u op&#x0107;oj populaciji u svijetu, pa tako i me&#x0111;u studentima. (<xref ref-type="bibr" rid="r1"><italic>1</italic></xref>, <xref ref-type="bibr" rid="r2"><italic>2</italic></xref>) Studenti medicine su po nizu zna&#x010D;ajki specifi&#x010D;na skupina. Naime, u&#x010D;estalost depresivnosti i anksioznosti bila je i u prepandemijskom periodu u ovoj skupini ve&#x0107;a, kako u odnosu na druge kategorije studenata, tako i na op&#x0107;u populaciju. (<xref ref-type="bibr" rid="r3"><italic>3</italic></xref>-<xref ref-type="bibr" rid="r6"><italic>6</italic></xref>) Zbog bliske povezanosti sa zdravstvenim sustavom, koji je u pandemiji osobito prenapregnut, studenti medicine mogu u okolnostima pandemije biti izlo&#x017E;eni dodatnom stresu.</p>
<p>Studij medicine izuzetno je zahtjevan, i emocionalno i intelektualno, a stresori s kojima se studenti suo&#x010D;avaju odnose se npr. na veliki opseg gradiva, nedostatak slobodnog vremena, kompeticiju me&#x0111;u kolegama, strah od neuspjeha, o&#x010D;ekivanja obitelji i izlo&#x017E;enost ljudskoj patnji. Za studij medicine karakteristi&#x010D;na je i promjena akademskih uvjeta prilikom prelaska s pretklini&#x010D;kog na klini&#x010D;ki dio nastave. Shodno tomu, pojedina istra&#x017E;ivanja utvrdila su razlike u u&#x010D;estalosti psihi&#x010D;kih smetnji izme&#x0111;u studenata pretklini&#x010D;kog i klini&#x010D;kog dijela nastave, koje su obi&#x010D;no bile ja&#x010D;e izra&#x017E;ene u pretklini&#x010D;kim godinama. (<xref ref-type="bibr" rid="r7"><italic>7</italic></xref>) Naime, u prve tri godine studij je uglavnom usmjeren na didakti&#x010D;ke ili bazi&#x010D;ne znanosti, dok su od &#x010D;etvrte do &#x0161;este godine studenti uklju&#x010D;eni u klini&#x010D;ku nastavu. U prvoj godini studija, osim toga, prisutni su stresovi vezani uz prelazak iz srednje &#x0161;kole na fakultet, &#x010D;e&#x017E;nja za obiteljskim domom, nedovoljna upu&#x0107;enost u akademske procedure i zahtjeve, kao i o&#x010D;ekivanja obitelji vezana uz studij. Me&#x0111;utim, postoje i istra&#x017E;ivanja koja nisu na&#x0161;la razliku u u&#x010D;estalosti mentalnih poreme&#x0107;aja izme&#x0111;u pretklini&#x010D;kih i klini&#x010D;kih godina studija, (<xref ref-type="bibr" rid="r8"><italic>8</italic></xref>) kao i ona koja su na&#x0161;la vi&#x0161;u u&#x010D;estalost depresije u klini&#x010D;kim godinama. (<xref ref-type="bibr" rid="r9"><italic>9</italic></xref>) Istra&#x017E;ivanja, osim toga, pokazuju da su studenti medicine rje&#x0111;e skloni tra&#x017E;iti pomo&#x0107; kada imaju psihi&#x010D;ke pote&#x0161;ko&#x0107;e. (<xref ref-type="bibr" rid="r7"><italic>7</italic></xref>) U njih je &#x010D;e&#x0161;&#x0107;e izra&#x017E;en perfekcionizam, zbog &#x010D;ega mogu stresno reagirati na promjene u na&#x010D;inu rada. (<xref ref-type="bibr" rid="r10"><italic>10</italic></xref>)</p>
<p>U vrijeme pandemije psihi&#x010D;kom optere&#x0107;enju studenata mogu pridonijeti i drugi stresovi, kao &#x0161;to su &#x010D;este i nagle promjene rasporeda i na&#x010D;ina izvo&#x0111;enja nastave, uklju&#x010D;uju&#x0107;i nastavu <italic>online</italic>, izostanak vje&#x017E;bi, osobito klini&#x010D;kih, smanjeni kontakti s pacijentima i s kolegama. (<xref ref-type="bibr" rid="r11"><italic>11</italic></xref>) Osim toga, zbog informacija kojima raspola&#x017E;u, studenti medicine mogu biti svjesniji ozbiljnosti COVID-19. Iako je dodir s klini&#x010D;kim radom smanjen zbog pandemije, studenti su &#x010D;esto uklju&#x010D;eni u razli&#x010D;ite aktivnosti vezane uz pandemiju kao &#x0161;to je npr. pomo&#x0107; epidemiolo&#x0161;kim slu&#x017E;bama. Tako&#x0111;er je prisutna zabrinutost oko zavr&#x0161;etka studija, kao i stjecanja odgovaraju&#x0107;ih kompetencija tijekom studija s obzirom na ograni&#x010D;enost u obavljanju klini&#x010D;kih vje&#x017E;bi. (<xref ref-type="bibr" rid="r10"><italic>10</italic></xref>, <xref ref-type="bibr" rid="r11"><italic>11</italic></xref>) Velik broj sati klini&#x010D;ke nastave nije mogu&#x0107;e jednostavno zamijeniti <italic>online</italic> platformama, a istovremena &#x017E;elja za studiranjem i usvajanjem novih znanja i vje&#x0161;tina u konfliktu je sa strahom i prate&#x0107;im u&#x010D;incima anksioznosti i stresa zbog zaraze i prijenosa bolesti.</p>
<p>Me&#x0111;utim, dosada&#x0161;nja istra&#x017E;ivanja koja su ispitivala pojavnosti depresije, anksioznosti i stresa studenata medicine u vrijeme pandemije uglavnom su bila presje&#x010D;na i ukazala su na vrlo &#x0161;irok raspon njihove zastupljenosti. (<xref ref-type="bibr" rid="r12"><italic>12</italic></xref>-<xref ref-type="bibr" rid="r15"><italic>15</italic></xref>) Istra&#x017E;ivanja koja su prospektivno mjerila mentalno zdravlje op&#x0107;enito su rijetka te su pretragom literature na&#x0111;ene samo dvije takve studije, od kojih je jedna predtisak. (<xref ref-type="bibr" rid="r11"><italic>11</italic></xref>, <xref ref-type="bibr" rid="r16"><italic>16</italic></xref>) Tu su i istra&#x017E;ivanja koja su u pandemiji presje&#x010D;no ispitala mentalno zdravlje i usporedila ga s ranijim presje&#x010D;nim rezultatima u populacijama studenata istih fakulteta. (<xref ref-type="bibr" rid="r17"><italic>17</italic></xref>) U navedenim istra&#x017E;ivanjima opisani su razli&#x010D;iti ishodi u pandemijskom periodu: od porasta anksioznosti do nepromijenjenog stanja, pa i pobolj&#x0161;anja mentalnog zdravlja. (<xref ref-type="bibr" rid="r11"><italic>11</italic></xref>, <xref ref-type="bibr" rid="r16"><italic>16</italic></xref>, <xref ref-type="bibr" rid="r17"><italic>17</italic></xref>) Zbog ove kontradiktornosti nije jasno je li i na koji na&#x010D;in COVID-19 povezan s promjenama u mentalnom zdravlju studenata medicine. Osim toga, ova istra&#x017E;ivanja ukazuju da protok vremena kao i promjene u primjeni epidemiolo&#x0161;kih mjera mogu utjecati na pojavnost ovih smetnji. Stoga je bilo potrebno ispitati mentalno zdravlje studenata medicine nakon godinu i pol od po&#x010D;etka pandemije.</p>
<p>Cilj ovog istra&#x017E;ivanja bio je ispitati prisutnost depresije, anksioznosti i stresa u populaciji studenta medicinskog fakulteta te ustanoviti postoje li razlike izme&#x0111;u studenata pretklini&#x010D;kih i klini&#x010D;kih godina studija, kao i s obzirom na sociodemografske i akademske varijable.</p>
<sec sec-type="other1">
<title>Metode</title>
<p>Istra&#x017E;ivanje je provedeno <italic>online</italic>. U prikupljanju podataka kori&#x0161;tena je metoda snje&#x017E;ne grude, &#x0161;to zna&#x010D;i da je upitnik podijeljen putem <italic>Google</italic>-obrasca na dru&#x0161;tvenim mre&#x017E;ama u grupama studenata Medicinskog fakulteta Sveu&#x010D;ili&#x0161;ta u Zagrebu koji su zamoljeni da upitnik pro&#x0161;ire dalje studentima istog fakulteta drugim sredstvima komunikacije: e-po&#x0161;tom i putem dru&#x0161;tvenih mre&#x017E;a. Podatci su prikupljeni od 1. rujna do 20. rujna 2021., a studenti su pristupanjem upitniku dali svoj informirani pristanak za sudjelovanje u istra&#x017E;ivanju. U uputi je istaknuto da je ispitivanje dobrovoljno, anonimno, da imaju pravo odustati u bilo kojem trenutku te da su istra&#x017E;iva&#x010D;i obvezni za&#x0161;tititi tajnost podataka. Istra&#x017E;ivanje je odobrilo Eti&#x010D;ko povjerenstvo Fakulteta. Upitnik je u potpunosti ispunilo 206 studenata, prosje&#x010D;ne dobi 22,56 godina SD 2,73 (raspon 18 &#x2013; 31). U uzorku je bilo 110 (55%) &#x017E;ena, a 90 (45%) mu&#x0161;karaca, dok se 6 (2,9%) osoba nije izjasnilo u svezi spola.</p>
<p>Istra&#x017E;ivanje se sastojalo od upitnika vezanih uz sociodemografske podatke i akademsku situaciju te Ljestvice depresivnosti, anksioznosti i stresa (<italic>Depression, Anxiety and Stress Scale,</italic> DASS-21). DASS-21 ima 21 &#x010D;esticu i mjeri tri kategorije emocionalnih smetnji: depresivnost, anksioznost i stres. (<xref ref-type="bibr" rid="r18"><italic>18</italic></xref>, <xref ref-type="bibr" rid="r19"><italic>19</italic></xref>) Svaka od tri podljestvice ima sedam &#x010D;estica po kategoriji, a ispitanici na Likertovoj ljestvici procjenjuju koliko se tvrdnja odnosi na njih u rasponu od 0 &#x2013; &#x201E;uop&#x0107;e se nije odnosilo na mene&#x201C; do 3 &#x2013; &#x201E;potpuno ili ve&#x0107;inu vremena se odnosilo na mene&#x201C;. &#x010C;estice su zbrojene za pojedinu podljestvicu i pomno&#x017E;ene s dva. Normalnim skorom na ljestvici depresije smatrao se skor 0 &#x2013; 9, za anksioznost 0 &#x2013; 7 i za stres 0 &#x2013; 14. Trebalo je procijeniti smetnje u zadnjih tjedan dana. Upitnik je ranije validiran u hrvatskoj populaciji. (<xref ref-type="bibr" rid="r20"><italic>20</italic></xref>) Cronbach alfa u ovom uzorku iznosila je za podljestvicu depresivnosti 0,923, za anksioznost 0,918, a za podljestvicu stresa 0,907.</p>
<p>Prikupljeni su tako&#x0111;er podatci o spolu i dobi, partnerskom odnosu (tj. jesu li u vezi), na&#x010D;inu stanovanja, kroni&#x010D;nim bolestima, bavljenju tjelesnom aktivnosti, pu&#x0161;enju, uzimanju psihoaktivnih tvari (PAT), kao i akademski podatci o prosjeku ocjena, godini studija i broju sati koje prosje&#x010D;no dnevno provedu u u&#x010D;enju. Ispitanici su podijeljeni na dvije skupine prema tome pripadaju li pretklini&#x010D;kim ili klini&#x010D;kim godinama studija, pri &#x010D;emu su pretklini&#x010D;kim godinama smatrane prve tri godine studija, a klini&#x010D;kim godinama druge tri godine studija.</p>
<sec>
<title>Statistika</title>
<p>U&#x010D;injena je deskriptivna statistika te ispitana normalnost raspodjele. Kontinuirane varijable nisu bile normalno raspodijeljene u uzorku te su u njihovoj analizi kori&#x0161;tene neparametrijske statisti&#x010D;ke metode. Kategorijske varijable su uspore&#x0111;ene hi-kvadrat testom, a za usporedbu kontinuiranih varijabli kori&#x0161;tene su Spearmanove korelacije, Mann-Whitneyev test te Kruskal-Wallisov test. Kod dobivenih statisti&#x010D;ki zna&#x010D;ajnih vrijednosti u&#x010D;injena je Bonferroni-korekcija za vi&#x0161;estruke usporedbe. U&#x010D;injene su tri vi&#x0161;estruke logisti&#x010D;ke regresije za zavisne varijable depresiju, anksioznosti i stres, a kao nezavisne varijable uvr&#x0161;tene su one koje su se u ranijim analizama pokazale statisti&#x010D;kim zna&#x010D;ajnim. Rezultati su analizirani programom SPSS 25, a p&lt;0,05 smatran je statisti&#x010D;ki zna&#x010D;ajnim.</p>
</sec>
</sec>
<sec sec-type="other2">
<title>Rezultati</title>
<p>Istra&#x017E;ivanje je pokazalo da 25,7% studenata medicine ima depresivne smetnje, 26,7% ima zna&#x010D;ajne anksiozne smetnje, a 15% ispitanika ima zna&#x010D;ajne simptome stresa. Pretklini&#x010D;kim godinama studija pripadalo je 51% studenata. Deskriptivni podatci za kategorijske (sociodemografski podatci) te kontinuirane varijable (akademske varijable, podljestvice mentalnog zdravlja) prikazani su u <xref ref-type="table" rid="t1">Table 1</xref>. Ovom tablicom su tako&#x0111;er prikazani rezultati hi-kvadrat testa vezano uz ispitivanje razlike izme&#x0111;u sociodemografskih varijabli te pripadnosti pretklini&#x010D;koj i klini&#x010D;koj skupini. Tako&#x0111;er su istom tablicom prikazani i rezultati Mann-Whitneyeva testa vezano uz ispitivanje razlike izme&#x0111;u dobi, akademskih varijabli prosjeka ocjena i prosje&#x010D;nih sati u&#x010D;enja te podljestvica mentalnog zdravlja prema pripadnosti pretklini&#x010D;koj, odnosno klini&#x010D;koj skupini.</p>
<table-wrap id="t1" position="float">
<label>Table 1</label><caption><title>Comparison between students of preclinical and clinical years of training according to sociodemographic and academic variables and DASS-21 subscales</title>
</caption>
<table frame="hsides" rules="groups">
<col width="30.5%"/>
<col width="22.56%"/>
<col width="18.9%"/>
<col width="14.02%"/>
<col width="14.02%"/>
<thead>
<tr>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.75pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"><bold>Sociodemografske varijable</bold><break/><bold>Sociodemographic variable</bold>s</th>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.50pt; border-top: solid 0.75pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"><bold>Pretklinika</bold><break/><bold>N(%)/sr. rang</bold><break/><bold>Preclinical</bold><break/><bold>N(%)average rank</bold></th>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.50pt; border-top: solid 0.75pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"><bold>Klinika</bold><break/><bold>N(%)/sr. rang</bold><break/><bold>Clinical</bold><break/><bold>N(%)average rank</bold></th>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.50pt; border-top: solid 0.75pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"><bold>&#x03C7;/U</bold></th>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.50pt; border-top: solid 0.75pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt"><bold>p</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">Spol/mu&#x0161;ki / Gender/male</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">53(50,3)</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">37(36,6)</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">4,607</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">0,034</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">Partnerski odnos/da / Partner relations/yes</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">45(42,9)</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">52(51,5)</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">1,538</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">0,246</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">Tjelesna aktivnost /da / Physical activity/yes</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">46(43,8)</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">58(57,4)</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">3,818</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">0,053</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">Pu&#x0161;enje/da<break/>/ Smoking/yes</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">39(37,1)</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">32(31,7)</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">0,679</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">0,464</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">Alkohol/da<break/>/ Alcohol/yes</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">13(12,4)</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">13(12,9)</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">4,123</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">0,127</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">PAT/da<break/>/ PAS/yes</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">15(14,3)</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">11(10.9)</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">0,538</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">0,532</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">Kroni&#x010D;ne bolesti/da / Chronic illness/yes</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">24(22,9)</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">22(21,8)</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">0,034</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">0,869</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">Dob / Age</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">142,81</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">68,63</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">1174,5</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">0,0001</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">Prosjek / Average grades</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">101,84</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">105,22</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">5128,5</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">0,678</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">Sati u&#x010D;enja / Hours of learning</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">99,6</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">107,56</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">4892,5</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">0,332</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">Depresivnost / Depression</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">111,85</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">94,82</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">4425,5</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">0,04</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">Anksioznost / Anxiety</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">104,16</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">102,81</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">5233,0</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">0,87</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.75pt" scope="row">Stres / Stress</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.75pt">100,86</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.75pt">106,24</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.75pt">5025,5</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.75pt">0,516</td>
</tr>
</tbody>
</table><table-wrap-foot>
<p>N &#x2013; broj ispitanika / number of participants; &#x03C7; &#x2013; koeficijent / coefficient; U &#x2013; Mann-Whitneyev koeficijent / Mann-Whitney coefficient; p &#x2013; statisti&#x010D;ka zna&#x010D;ajnost / statistical significance; PAT &#x2013; psihoaktivne tvari / psychoactive substances</p>
</table-wrap-foot></table-wrap>
<p>Sociodemografske i akademske varijable, kao i varijable vezane uz mentalno zdravlje, nisu se razlikovale izme&#x0111;u studenata pretklini&#x010D;kih i klini&#x010D;kih godina studija, osim varijable depresivnosti koja je bila vi&#x0161;e izra&#x017E;ena u studenata pretklini&#x010D;kih godina studija, no ta se razlika gubila nakon korekcije za vi&#x0161;estruke usporedbe po Bonferroniju.</p>
<p>U&#x010D;injene su Spearmanove korelacije kontinuiranih varijabli depresivnosti, anksioznosti i stresa s dobi te prosjekom ocjena, dnevno provedenim satima u u&#x010D;enju i godinom studija. Vrijednosti su prikazane <xref ref-type="table" rid="t2">Table 2</xref>. Zna&#x010D;ajnima su se pokazale negativne korelacije izme&#x0111;u depresivnosti, anksioznosti i stresa te prosjeka ocjena kao i pozitivna korelacija anksioznosti i sati provedenih u u&#x010D;enju. Depresivnost je bila zna&#x010D;ajno vi&#x0161;e izra&#x017E;ena &#x0161;to je godina studija bila ni&#x017E;a.</p>
<table-wrap id="t2" position="float">
<label>Table 2</label><caption><title>Spearman&#x2019;s correlations between variables of depression, anxiety and stress with age, daily hours spent on learning, average grades, and year of study</title>
</caption>
<table frame="hsides" rules="groups">
<col width="30.02%"/>
<col width="10%"/>
<col width="10%"/>
<col width="9.99%"/>
<col width="10%"/>
<col width="10%"/>
<col width="9.99%"/>
<col width="10%"/>
<thead>
<tr>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.75pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"></th>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.50pt; border-top: solid 0.75pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">1</th>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.50pt; border-top: solid 0.75pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">2</th>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.50pt; border-top: solid 0.75pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">3</th>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.50pt; border-top: solid 0.75pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">4</th>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.50pt; border-top: solid 0.75pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">5</th>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.50pt; border-top: solid 0.75pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">6</th>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.50pt; border-top: solid 0.75pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">7</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">1. depresivnost / depression</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"></td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"></td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"></td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"></td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"></td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt"></td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">2. anksioznost / anxiety</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">,731**</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"></td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"></td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"></td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"></td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt"></td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">3. stres / stress</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">,773**</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">,831**</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"></td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"></td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"></td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt"></td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">4. dob / age</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-,020</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-,078</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-,164*</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"></td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"></td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt"></td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">5. sati u&#x010D;enja / hours of learning</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">,031</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">,149*</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">,103</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-,005</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt"></td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt"></td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">6. prosjek / average grades</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-,212**</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-,238**</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-,184**</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">,281**</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-,015</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt"></td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.75pt" scope="row">7. godina studija / study year</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.75pt">-,169*</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.75pt">-,008</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.75pt">,033</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.75pt">-,778**</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.75pt">,053</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.75pt">-,014</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.75pt">-</td>
</tr>
</tbody>
</table><table-wrap-foot>
<p>* &#x2013; statisti&#x010D;ka zna&#x010D;ajnost &lt;0,05 / statistical significance &lt;0,05; ** &#x2013; statisti&#x010D;ka zna&#x010D;ajnost &lt; 0,01 / statistical significance &lt; 0,01</p>
</table-wrap-foot></table-wrap>
<p>Pojedine sociodemografske varijable uspore&#x0111;ene su Mann-Whitneyevim testom te Kruskal-Wallisovim testom prema ljestvicama mentalnog zdravlja. U analizi prema spolu studentice su imale zna&#x010D;ajno vi&#x0161;e izra&#x017E;enu anksioznost (U=3394,5; p=0,0001) kao i stres (U=3651,5; p=0,001), no ne i depresivnost. Studenti su se zna&#x010D;ajno razlikovali u mentalnom zdravlju prema partnerskom odnosu, odnosno oni koji su u vezi bili su manje depresivni (U=3888,5; p=0,002), te u stresu (U=4212; p=0,016), a prema anksioznosti nije bilo zna&#x010D;ajne razlike. Konzumacija psihoaktivnih tvari bila je povezana s vi&#x0161;e depresivnosti (U=1472; p=0,002), anksioznosti (U=1604; p=0,009) i stresa (U=1486,5; p=0,003). Rezultati su bili zna&#x010D;ajni i nakon provedene korekcije za vi&#x0161;estruke usporedbe po Bonferroniju.</p>
<p>U&#x010D;injene su potom tri vi&#x0161;estruke logisti&#x010D;ke regresijske analize u kojima su zavisne varijable bile depresija, anksioznost i stres, a prediktori dob i spol uvr&#x0161;teni su kao kontrolne varijable u prvom stupnju, dok su u drugom stupnju uvr&#x0161;tene nezavisne varijable koje su se prethodnim analizama pokazale zna&#x010D;ajnima: prosjek ocjena, dnevni sati u&#x010D;enja, pripadnost pretklini&#x010D;koj/klini&#x010D;koj skupini, partnerski odnos te uzimanje PAT. Ni&#x017E;i prosjek ocjena te partnerski odnos bili su zna&#x010D;ajni prediktori depresije, a spol, ni&#x017E;i prosjek i konzumacija PAT prediktori anksioznosti. &#x017D;enski spol i ve&#x0107;a konzumacija PAT bili su prediktori stresa. Rezultati su prikazani <xref ref-type="table" rid="t3">Table 3</xref>.</p>
<table-wrap id="t3" position="float">
<label>Table 3</label><caption><title>Logistic regression with depression, anxiety and stress as dependent variables and age, gender, partner status, average grades, hours daily spent on learning, use of psychoactive substances and preclinical/clinical group as predictors</title>
</caption>
<table frame="hsides" rules="groups">
<col width="35.37%"/>
<col width="24.39%"/>
<col width="24.39%"/>
<col width="15.85%"/>
<thead>
<tr>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.75pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">Sociodemografske<break/>varijable<break/>Sociodemographic<break/>variables</th>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.50pt; border-top: solid 0.75pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">Depresija<break/>Depression<break/>B</th>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.50pt; border-top: solid 0.75pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">Anksioznost<break/>Anxiety<break/>B</th>
<th valign="middle" align="left" scope="col" style="border-left: solid 0.50pt; border-top: solid 0.75pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">Stres<break/>Stress<break/>B</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">Dob / Age</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-,133</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-,063</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">-,171</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">Spol / Gender</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-,600</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-1,581*</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">-2,287*</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">Partnerski status / Partner status</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-1,128*</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-,637</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">-,936</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">Prosjek ocjena / Average grades</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-,598*</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-,787*</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">-,617</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">Sati u&#x010D;enja / Hours of learning</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">,145</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">,157</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">,060</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt" scope="row">PAT / PAS</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-,550</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.50pt">-1,181*</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.50pt">-1,611*</td>
</tr>
<tr>
<td valign="middle" align="left" style="border-left: solid 0.75pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.75pt" scope="row">Pretklinika/klinika / Preclinical/clinical</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.75pt">,745</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.50pt; border-bottom: solid 0.75pt">,457</td>
<td valign="middle" align="left" style="border-left: solid 0.50pt; border-top: solid 0.50pt; border-right: solid 0.75pt; border-bottom: solid 0.75pt">,779</td>
</tr>
</tbody>
</table><table-wrap-foot>
<p>* &#x2013; statisti&#x010D;ka zna&#x010D;ajnost &lt; 0,01 / statistical significance &lt; 0,01; PAT/PAS &#x2013; psihoaktivne tvari / psychoactive substances; B &#x2013; beta koeficijent / beta coefficient</p>
</table-wrap-foot></table-wrap>
<p>Na temelju dobivenih rezultata 28,1% ispitanika je preboljelo COVID-19, a 82% ispitanika je cijepljeno protiv bolesti COVID-19. Studenti podijeljeni na skupine onih koji jesu/nisu preboljeli COVID-19 kao i oni koji jesu/nisu cijepljeni nisu se razlikovali u ljestvicama mentalnog zdravlja te sociodemografskim i akademskim varijablama, osim &#x0161;to su studenti koji nisu cijepljeni bili zna&#x010D;ajno mla&#x0111;i (U=1403; p=0,0001) i &#x010D;e&#x0161;&#x0107;e zastupljeni u skupini pretklini&#x010D;kog studija (&#x03C7;=16,362; p=0,0001).</p>
</sec>
<sec sec-type="other3">
<title>Diskusija</title>
<p>Zastupljenost depresije, anksioznosti i stresa u ovom istra&#x017E;ivanju odgovara vrijednostima koje su kod studenata medicine opisane u metaanalizama u&#x010D;injenim prije pandemije, a koje ukazuju na prosje&#x010D;nu prevalenciju od 27% odnosno 28% za depresiju, (<xref ref-type="bibr" rid="r3"><italic>3</italic></xref>&#x2013;<xref ref-type="bibr" rid="r5"><italic>5</italic></xref>) te 30% za anksioznost. (<xref ref-type="bibr" rid="r6"><italic>6</italic></xref>) Rizici koji su opisani u tim metaanalizama bili su mla&#x0111;a dob, &#x017E;enski spol i lo&#x0161;a socijalna podr&#x0161;ka, (<xref ref-type="bibr" rid="r3"><italic>3</italic></xref>-<xref ref-type="bibr" rid="r6"><italic>6</italic></xref>) koji su potvr&#x0111;eni i u ovom istra&#x017E;ivanju.</p>
<p>Me&#x0111;utim, prevalencija anksioznosti, depresivnosti i stresa mo&#x017E;e se jako mijenjati u pandemiji u pojedinim njenim fazama. (<xref ref-type="bibr" rid="r21"><italic>21</italic></xref>) Istra&#x017E;ivanje Romi&#x0107;, et al. me&#x0111;u studentima medicine Sveu&#x010D;ili&#x0161;ta u Zagrebu, provedeno u sije&#x010D;nju 2021., pokazuje zna&#x010D;ajno vi&#x0161;e vrijednosti depresivnosti i anksioznosti u odnosu na one koji su na&#x0111;ene u na&#x0161;em istra&#x017E;ivanju. Stopa smrtnosti od bolesti COVID-19 u populaciji u tom periodu bila je zna&#x010D;ajno vi&#x0161;a, cjepivo je netom postalo dostupno, a prikupljanju podataka je neposredno prethodio potres u podru&#x010D;ju Banovine koji se jako osjetio i u Zagrebu, gdje je izazvao i materijalne &#x0161;tete. Stoga rezultati u ovoj studiji mogu biti dijelom odraz akutne reakcije na stres vezan uz potres. (<xref ref-type="bibr" rid="r15"><italic>15</italic></xref>) U na&#x0161;em istra&#x017E;ivanju u istoj populaciji osam mjeseci kasnije vrijednosti su usporedive s prepandemijskima (<xref ref-type="bibr" rid="r3"><italic>3</italic></xref>-<xref ref-type="bibr" rid="r6"><italic>6</italic></xref>), &#x0161;to govori u prilog prilagodbe studenata na okolnosti stresa. Mogu&#x0107;e je da ovoj prilagodbi doprinosi i njihova profesionalna identifikacija s budu&#x0107;om ulogom lije&#x010D;nika. Znanja koja stje&#x010D;u o bolesti COVID-19 i preventivnim mjerama mogu biti povezana sa smanjenjem stresa. (<xref ref-type="bibr" rid="r22"><italic>22</italic></xref>) U istra&#x017E;ivanju provedenom u lije&#x010D;ni&#x010D;koj populaciji u o&#x017E;ujku i travnju 2020. u Hrvatskoj pokazalo se da, unato&#x010D; ve&#x0107;oj izlo&#x017E;enosti virusu, zabrinutost oko mentalnog zdravlja nije izra&#x017E;enija u lije&#x010D;nika u odnosu na op&#x0107;u populaciju, niti je utvr&#x0111;ena lo&#x0161;ija kvaliteta &#x017E;ivota. (<xref ref-type="bibr" rid="r23"><italic>23</italic></xref>)</p>
<p>Tijekom pandemije u&#x010D;injena istra&#x017E;ivanja me&#x0111;u studenima nemedicinskih studija pokazuju zna&#x010D;ajno vi&#x0161;e vrijednosti na ljestvicama depresivnosti, anksioznosti i stresa u odnosu na prepandemijske vrijednosti. (<xref ref-type="bibr" rid="r24"><italic>24</italic></xref>, <xref ref-type="bibr" rid="r25"><italic>25</italic></xref>) U istra&#x017E;ivanju studenata rije&#x010D;kog sveu&#x010D;ili&#x0161;ta koje je u&#x010D;injeno tijekom trajanja pandemije zastupljenost depresivnosti iznosila je 51,6%. (<xref ref-type="bibr" rid="r24"><italic>24</italic></xref>) U istra&#x017E;ivanju s osje&#x010D;kog sveu&#x010D;ili&#x0161;ta, tako&#x0111;er uz uporabu DASS-21, bilo je 50,8% studenata s depresijom, 50,9% s anksiozno&#x0161;&#x0107;u te 49,9% s povi&#x0161;enim stresom. (<xref ref-type="bibr" rid="r25"><italic>25</italic></xref>) Vi&#x0161;i postotci anksioznosti, depresivnosti i stresa dobiveni su po&#x010D;etkom pandemije i u op&#x0107;oj populaciji Hrvatske. (<xref ref-type="bibr" rid="r26"><italic>26</italic></xref>) Usporedivi su s ovim rezultatima i oni studentske populacije u Europi i u drugim zemljama svijeta. (<xref ref-type="bibr" rid="r27"><italic>27</italic></xref>)</p>
<p>Malobrojne su studije koje su usporedile prepandemijske s pandemijskim vrijednostima depresivnosti, anksioznosti i stresa. Nalazi su razli&#x010D;iti, u jednoj od njih do&#x0161;lo je do porasta anksioznosti i stresa, ali ne i depresije; (<xref ref-type="bibr" rid="r11"><italic>11</italic></xref>) brazilska studija, koja je objavljena tek kao predtisak, ne nalazi promjene u odnosu na prepandemijsko vrijeme, (<xref ref-type="bibr" rid="r16"><italic>16</italic></xref>) a studija Bolatova, et al. &#x010D;ak navodi pobolj&#x0161;anje mentalnog zdravlja. (<xref ref-type="bibr" rid="r17"><italic>17</italic></xref>) Sva ova istra&#x017E;ivanja mjerila su mentalno zdravlje u po&#x010D;etnom valu pandemije pa je mogu&#x0107;e da s navikavanjem na pandemijske uvjete do&#x0111;e i do smanjenja vrijednosti i da se one pribli&#x017E;e onima prepandemijskim. Poznato je da navikavanje na situaciju smanjuje anksioznost. (<xref ref-type="bibr" rid="r21"><italic>21</italic></xref>) Isto je vidljivo i usporedbom rezultata ove studije s rezultatima istra&#x017E;ivanja Romi&#x0107;, et al. prikupljenim osam mjeseci ranije. (<xref ref-type="bibr" rid="r15"><italic>15</italic></xref>) Mogu&#x0107;e je da je nastava <italic>online</italic>, koju su studenti uglavnom i procjenjivali kao manje zahtjevnu, smanjila akademski stres studenata medicine koji je ina&#x010D;e u ve&#x0107;ini istra&#x017E;ivanja, pa i u ovom, povezan s vi&#x0161;e depresivnosti, anksioznosti i stresa. (<xref ref-type="bibr" rid="r10"><italic>10</italic></xref>, <xref ref-type="bibr" rid="r24"><italic>24</italic></xref>, <xref ref-type="bibr" rid="r28"><italic>28</italic></xref>)</p>
<p>Akademski uspjeh mjeren kroz prosjek ocjena bio je jedan od najva&#x017E;nijih prediktora depresije i anksioznosti, a pozitivno je zna&#x010D;ajno korelirao i sa stresom. Vrlo te&#x017E;ak studij koji zahtjeva znatna odricanja uvijek je vezan uz nagradu u obliku akademskog uspjeha, a ako uspjeh izostaje dolazi do porasta anksioznosti, depresivnosti i stresa. Akademski uspjeh je bio jedan od prediktora depresivnosti i u istra&#x017E;ivanju Be&#x0107;irevi&#x0107;, et al. (<xref ref-type="bibr" rid="r24"><italic>24</italic></xref>) Ocjene su se pokazale povezanima s ovim ishodima i u drugim istra&#x017E;ivanjima u&#x010D;injenim prije i tijekom pandemije. (<xref ref-type="bibr" rid="r13"><italic>13</italic></xref>, <xref ref-type="bibr" rid="r16"><italic>16</italic></xref>, <xref ref-type="bibr" rid="r27"><italic>27</italic></xref>, <xref ref-type="bibr" rid="r29"><italic>29</italic></xref>) Mogu&#x0107;e je da su oni s vi&#x0161;im prosjekom ocjena predaniji samoedukaciji i imaju vi&#x0161;e znanja o bolesti COVID-19. Informiranost daje osje&#x0107;aj sigurnosti i smanjuje anksioznost i stres. (<xref ref-type="bibr" rid="r10"><italic>10</italic></xref>) Oni koji imaju ni&#x017E;e ocjene mo&#x017E;da imaju i ni&#x017E;e samopo&#x0161;tovanje. Ni&#x017E;i akademski prosjek ocjena i ranije je opisan kao rizik za depresiju u studentskoj populaciji, (<xref ref-type="bibr" rid="r30"><italic>30</italic></xref>) a u studiju Bolatova, et al. u onih u kojih je tijekom pandemije do&#x0161;lo do pada u akademskom uspjehu ja&#x010D;e se razvijala depresivnost i anksioznost. (<xref ref-type="bibr" rid="r17"><italic>17</italic></xref>) Mo&#x017E;e se pretpostaviti da je mentalno zdravlje uvjet za uspjeh na studiju, kao i da uspjeh na studiju pove&#x0107;ava samopouzdanje i dovodi do boljeg mentalnog zdravlja. Tako&#x0111;er je zabilje&#x017E;ena niska, ali statisti&#x010D;ki zna&#x010D;ajna pozitivna korelacija prosje&#x010D;nog dnevnog broja sati u&#x010D;enja i simptoma anksioznosti, odnosno oni studenti koji u prosjeku vi&#x0161;e vremena dnevno utro&#x0161;e na u&#x010D;enje pokazuju izra&#x017E;enije simptome anksioznosti. Mogu&#x0107;e je da osobe koje su anksioznije zbog svoje anksioznosti vi&#x0161;e u&#x010D;e jer se boje neuspjeha, kao i da du&#x017E;e u&#x010D;enje bez dovoljno odmora mo&#x017E;e dovesti do porasta anksioznosti. (<xref ref-type="bibr" rid="r10"><italic>10</italic></xref>) Povi&#x0161;ena anksioznost mo&#x017E;e pogor&#x0161;avati koncentraciju te je za svladavanje gradiva potrebno vi&#x0161;e vremena. (<xref ref-type="bibr" rid="r7"><italic>7</italic></xref>, <xref ref-type="bibr" rid="r10"><italic>10</italic></xref>)</p>
<p>Rad od ku&#x0107;e zahtijeva bolju organiziranost i samodisciplinu kao i prilagodbu navika u&#x010D;enja. (<xref ref-type="bibr" rid="r31"><italic>31</italic></xref>) U uvjetima slabije institucijske podr&#x0161;ke mo&#x017E;e se o&#x010D;ekivati da &#x0107;e se djevojke bolje sna&#x0107;i jer imaju razvijeniju samoregulaciju u u&#x010D;enju, (<xref ref-type="bibr" rid="r32"><italic>32</italic></xref>) no to se nije pokazalo to&#x010D;nim. One su, naime, i u ovom istra&#x017E;ivanju u&#x010D;injenom u doba pandemije imale vi&#x0161;e vrijednosti na ljestvicama anksioznosti i stresa. &#x017D;ene su ina&#x010D;e sklonije depresivnosti kao i anksioznosti, a opisano je da i ja&#x010D;e reagiraju na stres i vi&#x0161;e razvijaju poreme&#x0107;aje prilagodbe i posttraumatski stresni poreme&#x0107;aj. (<xref ref-type="bibr" rid="r10"><italic>10</italic></xref>, <xref ref-type="bibr" rid="r33"><italic>33</italic></xref>) Uzroci toga su vi&#x0161;estruki, a obuhva&#x0107;aju biolo&#x0161;ke te psihosocijalne i sociokulturalne &#x010D;imbenike. (<xref ref-type="bibr" rid="r3"><italic>3</italic></xref>-<xref ref-type="bibr" rid="r6"><italic>6</italic></xref>) Vi&#x0161;e presje&#x010D;nih istra&#x017E;ivanja ukazalo je na povi&#x0161;ene vrijednosti depresivnosti, anksioznosti i stresa u studentica medicine. (<xref ref-type="bibr" rid="r13"><italic>13</italic></xref>, <xref ref-type="bibr" rid="r14"><italic>14</italic></xref>, <xref ref-type="bibr" rid="r34"><italic>34</italic></xref>) Prospektivno istra&#x017E;ivanje u Brazilu &#x010D;ak je na&#x0161;lo blago pobolj&#x0161;anje mentalnog zdravlja u skupini &#x017E;ena tijekom pandemije. (<xref ref-type="bibr" rid="r17"><italic>17</italic></xref>) Me&#x0111;utim, &#x0161;est studenata se nije izjasnilo po spolu pa je to moglo utjecati na rezultate koji su se ticali spolne raspodjele. Istra&#x017E;ivanje Romi&#x0107;, et al. nije na&#x0161;lo razlike u spolnoj raspodjeli. (<xref ref-type="bibr" rid="r15"><italic>15</italic></xref>)</p>
<p>Pokazalo se da studenti koji su u partnerskoj vezi imaju bolje mentalno zdravlje. Istra&#x017E;ivanja ukazuju da su studenti koji su navodili da &#x017E;ive sami imali vi&#x0161;i rizik za psihi&#x010D;ke pote&#x0161;ko&#x0107;e tijekom pandemije jer je smanjenje kontakta na studiju dovelo do osje&#x0107;aja izoliranosti i usamljenosti. (<xref ref-type="bibr" rid="r16"><italic>16</italic></xref>) Usamljenost je i u prepandemijskim istra&#x017E;ivanjima u studenata medicine rizi&#x010D;ni &#x010D;imbenik za niz lo&#x0161;ih psiholo&#x0161;kih ishoda pa i suicidalnost, depresiju i anksioznost. (<xref ref-type="bibr" rid="r30"><italic>30</italic></xref>) Socijalna podr&#x0161;ka koja je povezana s tim je li netko u vezi jedna je od najstabilnijih poveznica boljega mentalnog zdravlja. (<xref ref-type="bibr" rid="r12"><italic>12</italic></xref>)</p>
<p>Ovo istra&#x017E;ivanje je ukazalo da je uporaba psihoaktivnih tvari bila &#x010D;e&#x0161;&#x0107;a u studenata koji su bili depresivniji, anksiozniji i imali vi&#x0161;u razinu stresa. Nije bilo specificirano o kojim se psihoaktivnim tvarima radi te ne mo&#x017E;emo razlu&#x010D;iti radi li se o kanabisu, sedativima ili te&#x017E;im drogama. Rezultati, me&#x0111;utim, nisu ukazali na povezanost s uporabom alkohola i pu&#x0161;enjem, premda su ranije studije ukazale da je i njihova uporaba povezana s lo&#x0161;ijim ishodima mentalnog zdravlja u populaciji studenata medicine. (<xref ref-type="bibr" rid="r35"><italic>35</italic></xref>, <xref ref-type="bibr" rid="r36"><italic>36</italic></xref>) Ovaj rezultat podupiru i druga istra&#x017E;ivanja koja su prou&#x010D;avala povezanost konzumacije razli&#x010D;itih psihoaktivnih tvari s pojavno&#x0161;&#x0107;u depresije, anksioznosti i stresa kod studenata. Ona su utvrdila kako se pojavnost navedenih simptoma pove&#x0107;ava u onih ispitanika koji konzumiraju psihoaktivne tvari. (<xref ref-type="bibr" rid="r35"><italic>35</italic></xref>) Isti rezultati opisani su i vezano uz pandemiju u op&#x0107;oj populaciji. (<xref ref-type="bibr" rid="r22"><italic>22</italic></xref>) Me&#x0111;utim, nije posve jasno koriste li ispitanici psihoaktivne tvari kako bi ubla&#x017E;ili ve&#x0107; postoje&#x0107;e psihi&#x010D;ke tegobe ili je njihova konzumacija &#x010D;imbenik koji dovodi do pojavnosti navedenih pote&#x0161;ko&#x0107;a. Ve&#x0107;ina autora se sla&#x017E;e kako je vjerojatno rije&#x010D; o kombinaciji obaju &#x010D;imbenika. (<xref ref-type="bibr" rid="r22"><italic>22</italic></xref>, <xref ref-type="bibr" rid="r35"><italic>35</italic></xref>, <xref ref-type="bibr" rid="r36"><italic>36</italic></xref>)</p>
<p>Premda se tjelesna aktivnost smatra za&#x0161;ti&#x0107;uju&#x0107;im &#x010D;imbenikom, (<xref ref-type="bibr" rid="r25"><italic>25</italic></xref>, <xref ref-type="bibr" rid="r37"><italic>37</italic></xref>, <xref ref-type="bibr" rid="r38"><italic>38</italic></xref>) u ovom istra&#x017E;ivanju nije bilo povezanosti tjelesne aktivnosti s mentalnim zdravljem. Istra&#x017E;ivanje me&#x0111;u studentima zdravstvenih studija u Osijeku u&#x010D;injeno u vrijeme pandemije tako&#x0111;er nije na&#x0161;lo ovu povezanost. (<xref ref-type="bibr" rid="r25"><italic>25</italic></xref>) U doba pandemije tjelesna aktivnost vi&#x0161;e se koncentrira na pojedina&#x010D;ne aktivnosti u prirodi, a manje na grupne sportove te je socijalna komponenta koja pridonosi povoljnijim ishodima bavljenja tjelesnom aktivno&#x0161;&#x0107;u vjerojatno bila manje izra&#x017E;ena.</p>
<p>Ovo istra&#x017E;ivanje je imalo za cilj ispitati i postoje li razlike izme&#x0111;u pretklini&#x010D;kih i klini&#x010D;kih godina u mentalnom zdravlju, no one nisu na&#x0111;ene. Ovo je u skladu s dijelom istra&#x017E;ivanja koja tako&#x0111;er ne nalaze razlike, (<xref ref-type="bibr" rid="r8"><italic>8</italic></xref>, <xref ref-type="bibr" rid="r39"><italic>39</italic></xref>) ali prepandemijska istra&#x017E;ivanja u kojima su uspore&#x0111;ivani studenti pretklini&#x010D;kih i klini&#x010D;kih godina studija medicine pokazuju razli&#x010D;ite rezultate. (<xref ref-type="bibr" rid="r7"><italic>7</italic></xref>, <xref ref-type="bibr" rid="r9"><italic>9</italic></xref>) Tijekom pandemije u&#x010D;injena istra&#x017E;ivanja kojima se uspore&#x0111;uje razina simptoma anksioznosti kod studenata pretklinike i klinike pokazuju izra&#x017E;enije simptome anksioznosti kod studenata pretklini&#x010D;kih godina studija. (<xref ref-type="bibr" rid="r34"><italic>34</italic></xref>, <xref ref-type="bibr" rid="r40"><italic>40</italic></xref>, <xref ref-type="bibr" rid="r41"><italic>41</italic></xref>) U istra&#x017E;ivanju Romi&#x0107;, et al. studenti prve godine imali su zna&#x010D;ajno vi&#x0161;e izra&#x017E;ene simptome anksioznosti u odnosu na studente kasnijih godina studija. (<xref ref-type="bibr" rid="r15"><italic>15</italic></xref>) U na&#x0161;em istra&#x017E;ivanju studenti medicine prve godine su oni koji su zapravo tek upisali fakultet i jo&#x0161; nisu suo&#x010D;eni sa stresorima specifi&#x010D;nim za studij, &#x0161;to je moglo utjecati na rezultat.</p>
<p>Zbog trenutne pandemije COVID-19 u istra&#x017E;ivanje su bila uklju&#x010D;ena i pitanja o preboljenju i cijepljenju protiv COVID-19. Pokazalo se da se vi&#x0161;e ispitanika klini&#x010D;kih godina studija cijepilo, &#x0161;to je i razumljivo jer sa stjecanjem klini&#x010D;kog znanja raste i razumijevanje potrebe cijepljenja. (<xref ref-type="bibr" rid="r42"><italic>42</italic></xref>) Usporedbom dobivenih odgovora sa simptomima depresivnosti, anksioznosti i stresa nije uo&#x010D;ena statisti&#x010D;ki zna&#x010D;ajna razlika u izra&#x017E;enosti simptoma s obzirom na preboljenje i cijepljenje. Sli&#x010D;ni rezultati su vidljivi i u drugim istra&#x017E;ivanjima koja su ispitivala povezanost preboljenja COVID-19 s mentalnim zdravljem studenata medicine i koja tako&#x0111;er ne nalaze razlike izme&#x0111;u studenata pretklini&#x010D;kih i klini&#x010D;kih godina studija. (<xref ref-type="bibr" rid="r38"><italic>38</italic></xref>, <xref ref-type="bibr" rid="r43"><italic>43</italic></xref>)</p>
<p>U na&#x0161;em istra&#x017E;ivanju mjesto stanovanja nije bilo povezano s mjerama mentalnog zdravlja, premda u literaturi nalazimo razli&#x010D;ite podatke. (<xref ref-type="bibr" rid="r24"><italic>24</italic></xref>)</p>
<sec>
<title>Ograni&#x010D;enja istra&#x017E;ivanja</title>
<p>Istra&#x017E;ivanje je provedeno <italic>online</italic>, &#x0161;to je tijekom pandemije bila jedina mogu&#x0107;nost provedbe ovakvog istra&#x017E;ivanja, no to je ujedno i njegovo glavno ograni&#x010D;enje. Naime, kod ovakvih istra&#x017E;ivanja mogu&#x0107;a je samoselekcija sudionika, odnosno istra&#x017E;ivanju pristupaju oni sudionici koji su posebice zainteresirani za temu. Osim toga, uo&#x010D;eno je da neki ispitanici tijekom ovakvih ispitivanja odustanu ako se suo&#x010D;e s nejasno&#x0107;ama. Ispitivanje je presje&#x010D;no te ne omogu&#x0107;ava izvla&#x010D;enje zaklju&#x010D;aka o uzro&#x010D;no-posljedi&#x010D;nom odnosu. Ispitivanje depresivnosti i anksioznosti samoprocjenjuju&#x0107;im ljestvicama umjesto ljestvicama baziranim na klini&#x010D;kom razgovoru mo&#x017E;e biti povezano s pristrano&#x0161;&#x0107;u u rezultatima jer ispitanici mogu biti skloni odgovarati na socijalno prihvatljiv na&#x010D;in. (<xref ref-type="bibr" rid="r10"><italic>10</italic></xref>, <xref ref-type="bibr" rid="r43"><italic>43</italic></xref>) Ispitivanje je u&#x010D;injeno u vrijeme kada je prisutan zna&#x010D;ajan stres oko ispita. Naime, u studentskoj populaciji postoje oscilacije u zastupljenosti psihi&#x010D;kih smetnji vezano uz akademske obveze na fakultetu. (<xref ref-type="bibr" rid="r21"><italic>21</italic></xref>)</p>
<p>Podatci su prikupljeni na jednom medicinskom fakultetu te se ne mogu generalizirati na sve studente medicine u Hrvatskoj i studente medicine op&#x0107;enito.</p>
</sec>
</sec>
<sec sec-type="other4">
<title>Zaklju&#x010D;ci</title>
<p>Zaklju&#x010D;no, studenti pretklini&#x010D;kih i klini&#x010D;kih godina studija ne razlikuju se zna&#x010D;ajno prema depresivnosti, anksioznosti i stresu, no u studentica su smetnje mentalnog zdravlja izra&#x017E;enije. Uspjeh na fakultetu, partnerski status i uporaba psihoaktivnih tvari povezani su s mentalnim zdravljem. Promjene u tijeku i na&#x010D;inu studiranja mogu imati dugotrajne i odgo&#x0111;ene u&#x010D;inke na studente medicine. Stoga su potrebna istra&#x017E;ivanja koja bi pratila mentalno zdravlje tijekom studija medicine kako bi studenti mogli pravovremeno potra&#x017E;iti pomo&#x0107;.</p>
</sec>
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<ref-list>
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