Summary. The aim of this article is to provide evidence-based recommendations for early diagnosis of Alzheimer’s disease (AD) and hereby to give clinician the guidelines for optimal detection of patients with AD. Our intention is also to unify diagnostic schemes in accordance with our objective and specific possibilities. Basic diagnostic procedures primaruly are anamnesis and clinical examination with rational usage of neuroimaging, electrophysiological and laboratory procedures. Using these guidelines in medical practice in Croatia would be a solid basis for future epidemiological and clinical multicenter studies.