Summary. The aim of this article is to provide evidence-based recommendations for early diagnosis of Alzheimer’s disease (AD) and hereby to give clinican guidelines for optimal detection of patients with AD. Our intention is also to unify diagnostic schemes in accordance with our objective and specific possibilities. Basic diagnostic procedures primarily are anamnesis and clinical examination with rational usage of neuroimaging, electrophysiological and laboratory procedures. Using these guide- lines in medical practice in Croatia would be a good basis for future epidemiological and clinical multicentric studies.