BRONCHIOLITIS OBLITERANS ORGANIZING PNEUMONIA IN A PATIENT TREATED WITH AMIODARONE
Autori:
Zagorka Boras, Šimun Križanac, Neven Rakušić
Sažetak
Sažetak. Bronchiolitis obliterans s organiziranom pneumonijom (BOOP) jest točno određen kliničko-patološki entitet. Uzrok BOOP-a općenito je nepoznat, premda se povezuje s određenim bolestima ili uzimanjem različitih lijekova. Amiodaron je jedan od njih. Mi prikazuj emo bolesnika sa sekundamim BOOP-om na terapiju amiodaronom, koji se predstavio produktivnim kašljem, vrućicom, zaduhom i noćnim znojenjem tijekom dva mjeseca. Radiološki nalaz pluća pokazivao je difuzne n1rljaste i intersticij ske inf1ltrate. Imunofenotipizacija limfocita bronhoalveolamog ispirka (BAL) pokazala je izrazito nizak omjer CD4+: CD8+ limfocita. Dijagnoza BOOP-a potvrđena je transbronhalnom biopsijom pluća. Dva mjeseca nakon prestanka uzimanja amiodarona, simptomi bolesti su nestali, a radiološki nalaz pluća postao je uredan.
Summary
Summary. Bronchiolitis obliterans organizing pneumonia (BOOP) is a well-defined clinicopathological entity. The aetiology of BOOP is generally unknown, although it has been associated with specific diseases or various pharmaceutical drugs. The amiodarone is one of them. We report a patient with BOOP secondary to amiodarone therapy, who presented with cough, fever and sputum production, dyspnoea and night sweats lasting for two months. A chest radiograph showed bilateral patchy and interstitial infiltrates. Lymphocyte phenotyping of bronchoalveolar lavage fluid showed decreased ratio of CD4+:CD8+ lympho- cytes. Transbronchial lung biopsy established the diagnosis of BOOP. After stopping amiodarone therapy, symptoms disappeared and the chest radiograph remained normal within two months.
