MYELODYSPLASTIC SYNDROMES – NEW DISCOVERIES AND AN “OLD” MORPHOLOGY
Autori:
Gordana Kaić, Biljana Jelić Puškarić, Marina Pažur, Mia Šunjić Stakor, Slobodanka Ostojić Kolonić, Delfa Radić Krišto, Marko Martinović, Ika Kardum-Skelin
Sažetak
Mijelodisplastični sindrom heterogena je grupa bolesti koje dijele neka klinička i morfološka obilježja. Uzrok im je nepoznat. Budući da brz razvoj molekularne genetike omogućuje uvid u uzročne genske aberacije, danas se mogu odrediti neki patogenetski mehanizmi u nastanku mijelodisplastičnog sindroma. U ovom radu pokušat ćemo objasniti neka otkrića u tom području i njihovu vezu s citomorfološkim obilježjima, fenotipom mijelodisplastičnog sindroma.
Summary
Myelodysplastic syndromes (MDS) are a heterogenous group of diseases sharing some clinical and morphological features. Their cause is unknown. Since the rapid development of molecular genetics allows an insight into underlying genetic aberrations, today it is possible to determine some pathogenetic mechanisms in MDS. In this presentation we would like to explain some of the discoveries in this area and their connection to the myelodysplastic phenotype as seen in everyday cytomorphology work.
