MYELODYSPLASTIC SYNDROME IN A PATIENT WITH UNTREATED CHRONIC LYMPHOPROLIFERATIVE NEOPLASM
Ana Planinc-Peraica, Ana Reschner, Morana Kosanović-Bajić, Inga Mandac Rogulj, Gordana Kaić, Marin Kursar, Marko Martinović, Slobodanka Ostojić Kolonić, Delfa Radić-Krišto
High frequency of second malignancies is observed in chronic lymphoproliferative disease (LPD) patients. The simultaneous occurrence of myelodysplastic syndrome (MDS) with untreated LPD is extremely rare. Second haematological neoplasms are usually diagnosed incidentally during a routine clinical check-up, or due to discordant clinical or laboratory findings. We are reporting diagnostic procedures, clinical course, and treatment of a 65-year-old woman with chronic lym-phoproliferative neoplasm and MDS with excess of blasts type 2 (MDS-EB2). Neutropenia was the most aberrant finding. A diagnosis of two malignant haematological neoplasms was done by cytological analysis and immunophenotyping of bone marrow and peripheral blood cells. In spite of treating both neoplasms no satisfactory results were achieved and MDS progressed to acute myeloid leukaemia. In patients with lymphoproliferative neoplasms and cytopenias it is im-portant to find out other causes of these laboratory findings. In such patients the dominant disease should be treated. A concomitant MDS should be suspected and examined.