THE PRESENCE OF CD30 ON T CELLS IN THE INFLAMMATORY INFILTRATE OF ACUTE ATOPIC DERMATITIS
Autori:
Sažetak
Summary
Summary. Atopic dermatitis (AD) has cellular immunohistochemical features similar to those of allergic contact dermatitis (ACD). There is plenty of evidence for T-cell activation in this disease such us the presence of T-lymphocytes which carry CD30, CD3, CD4, CD45RO markers. The aim of this study was to show the presence of lymphocyte-surface antigens including CD30, CD3, CD4, CD45RO in patients with acute AD and to compare the presence of the same molecules in patients with acute ACD (nickel-induced) because of the possible morphologic difference of these two entities. The presence of the stated molecules is immunohistochemically evaluated in biopsies of lesional skin in dermis and epidermis. Biopsies were obtained from twelve patients suffering from acute AD and from thirteen patients with ACD. The results show statistically significant higher average of presence and also much higher range of presence of CD30+, CD3+, CD4+, CD45RO+ lympohocytes in dermis and epidermis of patients with AD compared to the average and range in patients with ACD. Statistically much higher average of CD30, CD3, CD4, CD45RO is noticed in those occasions more in dermis than in epidermis in both groups of patients. High number of CD30+ lymphocytes in patients with acute AD does not however correlate with the severity of the disease evaluated according to clinical score for the evaluation of the severity of the disease, so called the SCORAD-index (Severity Scoring of Atopic Dermatitis). Our results showed an association betwen CD30 expression and acute AD but not with acute ACD which could evaluate CD3 as the useful marker in differentiating these two diseases.
