PROCJENA SASTAVA TIJELA U BOLESNIKA S TIPOM 1 ŠEĆERNE BOLESTI METODOM BIOELEKTRIČNE IMPEDANCIJE

Janja Musulin, Maja Baretić, Vesna Šimegi-Đekić

Svrha rada. Usporediti sastav tijela bolesnika s tipom 1 dijabetesa (T1DM) i zdravih ispitanika te u bolesnika s T1DM-om analizirati sastav tijela s obzirom na dob, trajanje bolesti, regulaciju glikemije te doze inzulina. Ispitanici i ­metode. Uključen je 21 bolesnik s T1DM-om (srednje trajanje dijabetesa 13 godina, srednji HbA1c 7%). Srednja ukupna doza inzulina (TDD) bila je 50 i.j.; bazalnog 23 i.j., prandijalnog 27 i.j. Kontrolnu skupinu činilo je 14 zdravih ispitanika normalne težine. Sastav tijela analiziran je bioelektričnom impedancijom. Rezultati. Nije bilo razlike u sastavu tijela među skupinama. U bolesnika s T1DM-om nađena je pozitivna korelacija mase masti s TDD-om (r = 0,637; p < 0,05) i HbA1c (r = 0,499; p < 0,05). Bolesnici s T1DM-om podijeljeni su u podgrupe prema regulaciji glikemije: 10 zadovoljavajuća (HbA1c < 7,5%) – srednji HbA1c 6,82%, 11 nezadovoljavajuća (HbA1c > 7,5%) – srednji HbA1c 8,68%. Oni sa zadovoljavajućom regulacijom uzimali su 20 i.j. inzulina manje na dan (p = 0,035). Zaključak. U osoba s T1DM-om inzulin mijenja sastav tijela.

Aim. To compare body composition in patients with type 1 diabetes (T1DM) and healthy subjects, also to analyze body composition in T1DM patients regarding age, disease duration, glycemic control and insulin doses. Patients and methods. 21 T1DM patients were included (mean duration of diabetes was 13 years, mean HbA1c 7%). Mean total insulin dose (TDD) was 50 IU; basal 23 IU, prandial 27 IU. Control group were 14 healthy normal body weight subjects. Body composition was analyzed by bioelectrical impedance. Results. There was no difference in body composition between the two groups. T1DM patients had positive correlation of fat mass with TDD (r=0.637, p<0.05) and HbA1c (r=0.499, p<0.05). They were divided into subgroups according to glycemic control; 10 satisfactory (HbA1c<7.5%) mean HbA1c 6.82%, 11 unsatisfactory (HbA1c>7.5%) mean HbA1c 8.68%. Those with satisfactory control took 20 IU less insulin per day (p=0.035). Conclusion. In patients with T1DM insulin therapy changes body composition.