LEUKOCYTOCLASTIC VASCULITIS IN PRIMARY SJÖGREN SYNDROME: A CASE REPORT
Autori:
Nadica Laktašić-Žerjavić, Branimir Anić, Božidar Ćurković, Đurđica Babić-Naglić, Marin Nola, Davorin Lončarić
Sažetak
Sažetak. U radu je prikazana bolesnica s primarnim Sjögrenovim sindromom (SSjö) i kožnim leukocitoklastičkim vaskulitisom. Dijagnoza SS postavljena je na temelju klinički i objektivno utvrđene suhoće očiju i usta, karakterističnoga patohistološkog nalaza bioptata male slinovnice te pozitivnog nalaza protutijela SS-A. S obzirom na odsutnost znakova druge dobro definirane autoimune bolesti, postavljena je dijagnoza primarnog SSjö. Dijagnoza vaskulitisa potvrđena je patohistološki biopsijom kožne promjene. Bolesnica je uspješno liječena sustavnom primjenom niske doze glukokortikoida uz lokalnu simptomatsku terapiju sicca sindroma. Iako je SSjö jedna od najčešćih autoimunih bolesti, a vaskulitis jedna od karakterističnih ekstraglandularnih manifestacija bolesti, malo je podataka o kliničkim karakteristikama i raznolikosti vaskulitisa u primarnome SSjö.
Summary
Summary. We report a case of primary Sjögren’s syndrome (SSjö) with cutaneous leukocytoclastic vasculitis. The accurate diagnosis of SSjö was established based on objective signs and symptoms of ocular and oral dryness and characteristic appearance of a biopsy sample from a minor salivary gland, and presence of anti-SS-A autoantibody. Another autoimmune disorder was not present, so diagnosis of primary SSjö was established. Histologic finding of skin biopsy of purpuric lesion was typical for leukocytoclastic vasculitis. The patient was treated with small doses of glucocorticoids and with local symptomatic therapy for ocular and oral dryness. SSjö is one of the most common autoimmune disorders and vasculitis is one of the most characteristic extraglandular manifestations, but wide spectrum of cutaneous involvement in primary SSjö has been little studied.
