CLEAR CELL PAPILLARY RENAL CELL CARCINOMA IN A PATIENT WITH UROTHELIAL PAPILLARY CARCINOMA OF RENAL PYELON – REPORT OF A CASE
Vjekoslav Andrić, Monika Ulamec, Danijel Justinić, Božo Krušlin
According to the 2016 WHO classification most common histological types of kidney cancer arising from tubular epithelium are clear cell, papillary, and chromophobe carcinoma. New 2016 WHO classification of the urinary system tumors was complemented by new entities, such as tubulocystic carcinoma associated with the acquired renal cystic disease, carcinoma associated with MiT translocation, carcinoma associated with hereditary leiomyomatosis syndrome, and clear cell papillary renal cell carcinoma. The latter is histologically composed of tubules and papillae aligned with bland clear epithelial cells and characteristic linear nuclear arrangement away from the basal membrane. Immunohystochemical profile is characteristic for this entity. Tumor is described as indolent in nature. We are presenting a case report of a patient with a synchronous clear cell papillary renal cell carcinoma as an incidental finding in a nephrectomy specimen with clinical diagnosis of urothelial (transitional cell) carcinoma in the renal pyelon.